Drug Administration Study

DRUG ADMINISTRATION STUDY – EXECUTIVE SUMMARY

Important Note

Persons reading this information should use due care and attention in interpreting the results and should always have due regard to the individual characteristics of any greyhound being treated.  A “Safety Margin” of extra time accompanying the period of detection of each medication reported in these studies is suggested but the ANZGA provides withholding times and suggested “Safety Margins” purely as recommended guidelines and makes no representation and accepts no responsibility concerning the accuracy of these recommended guidelines and their applicability in the treatment of any particular greyhound.

Each study has been conducted based on results from two physically fit, adult greyhounds, in racing condition.  The results of the studies should therefore not be relied upon other than as a guide and readers must take account of the natural variation between greyhounds and their ability to metabolise and excrete the different medications and their breakdown products when interpreting each study.

PREAMBLE

At the Conference of delegates of the ANZGA held in Melbourne in September 1995, approval was gained from all Controlling Authorities to participate in a drug administration study of the most commonly prescribed and dispensed registered veterinary therapeutic medications associated with inadvertent, positive, post-race urine samples (swabs).

A project was then instituted to generate “Guideline Withholding Periods” rather than “Definitive Excretion Times”, as it must be appreciated that the latter would require the involvement of a much larger number of greyhounds, and consequently, a corresponding escalation of analytical costs.  Nonetheless, the protocols adopted throughout these studies are considered to be the most cost effective and informative ever to be undertaken in Australasia.

It should be noted that, throughout this report, a ‘Positive” finding may relate either to the parent drug and / or its metabolite (breakdown product) found in the post-administration urine sample, which will have been subjected to the same routine screening process by which all post-race urine samples are analysed.

This is not to imply that the medications, and / or their metabolites, would not be detectable for a longer period than that stated in the following Executive Summary Information Release, if more detailed or sophisticated procedures were to be employed.

It must be clearly stated that the dose rates of internal medications, and, the application rates of topical preparations, are at the average level of the therapeutic range recommended by the manufacturer of each particular product.  The use of a lower dose rate, or lesser quantity applied, or a shorter period of use, or a reduced period of application, may reduce the appropriate Withholding Guideline Period.  The use of a higher dose rate, or larger quantity applied, or a longer period of use, or an increased period of application, may increase the appropriate Withholding Guideline Period. The ANZGA, however, explicitly rejects any responsibility for any outcome resulting from interpretation, application, extrapolation, or variation of the stated procedures in the treatment of any greyhound or greyhounds.

Attention is again drawn to the fact that these studies are restricted solely to registered veterinary therapeutic medications prescribed or dispensed by registered veterinarians for the treatment of racing greyhounds.  No administration study will be contemplated in relation to illegally obtained, prohibited, or banned substances.

Persons requiring more detail as to any, or each, of the drug administration studies, should apply to the relevant local Controlling Authority, or, to the office of Greyhounds Australasia Limited, formerly known as the Australian and New Zealand Greyhound Racing Association Inc., P O Box 239 Springvale 3171

COPYRIGHT NOTICE: The information contained in this Executive Summary may not be published, amended, edited, or varied in any way without the written permission of Greyhounds Australasia Limited.

CRAIG TABERNER
Chief Executive Officer
1 January 2008

EXECUTIVE SUMMARY

Study
No.

Medication

Dose Rate Duration of
Administration

Detection
Period
(Minimum Indication only)

Withholding
Guidelines

1

Phenylbutazone (B.T.Z.)

100 mgm tablet
8 hourly for 5 days with food

48-72 hrs

120 hours
( 5 days)

2

Ketoprofen

10 mgm tablet
8 hourly for 5 days with food

24-48 hrs

72 hours
(3 days)

3

Flunixin

10 mgm
8 hourly for 3 days with food

48-72 hrs

96 hours
(4 days)

4

Aspirin

350 mgm
8 hourly for 5 days with food

48-72 hrs

96 hours
(4 days)

5

Indomethacin
(Cu-Algesic)

6 mgm once daily for 5 days

24 hrs

48 hours
(2 days)

6

Dermcusal containing
(a)  (Salicylic Acid)(b)  Dimethyl Sulphoxide       DMSO)

2ml of Dermcusal to each wrist joint
12 hourly for 5 days

(a) 6 days(b) 6 days

168 hours
(7 Days)

7

Isobutalone Gel
(a)  (Phenylbutazone)Isobutalone Gel
(b)  (Dimethyl/Sulphoxide
DMSO)Isobutalone Gel
(c) (Isepropylaminophenazone)

1 standard tspn of Isobutalone gel to each of two wrists
12 hourly for 5 days

(a)  6-7 days

192 hours
(8 days)

8

DMSO Roll On
(Dimethylsulphoxide)
* see 14 below

Rolled on 1 wrist and 1 hock 12 hourly, for  5 days, using enough to wet hair and skin.

6-7 days

Not yet defined

9

Myoton Cream
(a)  Phenylbutazone
(b)  Lignocaine
(c)  DMSO

1 teaspoonful 8 hourly for 5 days massaged into both wrist joints

(a) 4-5 days
(b) 7 days
(c) 2-5 days

Not yet defined due to lignocaine

10

Flucort-Domoso Roll On
(a)  Flumesthasone
(b)  DMSO Gel

Rolled on to both wrists
8 hourly for 5 days using enough to wet hair and skin

(a) 5-6 days
(b) 6-7 days

192 hours
(8 days)

It is imperative that this information be read in conjunction with the Notes and Preamble preceding these reports

11

Dexamethasone Injection
(Dexamethasone Sodium 2mg/ml)

1 millilitre (2 mg) injected under skin for one dose only

3-4 days

120 hours
(5 days)

12

DADA 250

1 ml injected into muscle
one dose only

Nil
after 24 hours

48 hours
(2 days)

13

Kynoselen Injection
(Heptaminol 5 mgm/ml)

5ml (25 mgm) injected under skin one dose only

3-4 days

120 hours
(5 days)

14

Domoso Roll-On (Repeat Study)
(Dimethylsulphoxide - DMSO)
(Topical Solution)

Rolled On 1 wrist and 1 hock
12 hourly for 5 days

5-6 days

192 hours
(8 days)

15

Voren
(Dexamethasone)

2 ml injected under skin
one dose only

7-8 days

Not defined

16

Apomorphine Hydrochloride

Dissolving 1 biling tablet in 2ml of Sterile water and injecting under the skin.

48 hours

72 hours

17

Clanobutin injection
(Bykahepar)

3ml injected into both thigh muscles
total dose of 6ml

7 days

Not defined

18

Bisolvon Tablets
(Bromhexine)

7.5 Tablets, twice daily for 5 days given orally

2 days in 1 dog
4 days in 1 dog

120 hours
(5 days)
Note variation in excretion rates

19

Clanobutin Injection
(Bykahepar)
Repeat of Study 17

3ml injected into both thigh muscles  Total dose of 6ml

9 days in 1 dog
10 days in 1 dog

264 hours
(11 days)
Note variation in excretion rates

20

Fortex Tonic
(Caffeine)

One Dose of 8 ml
(One Capful)

24 Hours

48 Hours
2 (Days)

It is imperative that this information be read in conjunction with the Notes and Preamble preceding these reports

21

Millophyline-V Tablets
(Etamyphilline)

3 tablets (=300mg)
3 Times Daily
for 5 Days

Exceeding 14 Days

Not yet defined

22

Prilocaine
Local Anaesthetic

One Injection of 2ml of 2% solution.
Under the Skin

1 day in one dog
2 days in one dog

72 hours (3 days)

23

Myoton Cream
(Repeat Study No. 1)
(a) Phyenylbutazone
(b) Lignocaine
(c) DMSO

One level teaspoonful applied to two wrists once daily for 5 days

(a) Nil at 5 days
(b) 11 days
(c) Nil at 5 days

Not yet defined due to Lignocaine

24

Myoton Cream
(Repeat Study No.2)
(a) Phenylbutazone
(b) Lignocaine
(c) DMSO

One level teaspoonful applied to one wrist once daily for 5 days

(a) Nil at 5 days
(b) 11 days
(c) Nil at 5 days

Not yet defined due to Lignocaine

25

Carprofen

60 mgm. orally,
8 Hourly for 3 doses,
then
60 mgm. 24 hourly, for
4 more doses

Nil at 24 hours

48 hours

26

Bone Radiol Liniment
(a)    Camphor
(b)    Menthol
(c)    Ammonia
(d)    Guaiacol
(e)    Creosote

Total of 5 ml applied
once daily for 5 days

Nil at 24 hours for all ingredients

48 hours

27

Trimolone Forte
(Triamcinolone
Acetonide 6 mgm/ml)

Total of 1 ml injected under the skin

4 days in one dog and 5 days in one dog.

144 hours
(6 Days)
Note variation in excretion rates.

28

Prednisolone
Acetate
Suspension

2ml (20mgm),
injected under the skin

Exceeding 7 days

Not yet defined

29

Buscopan Injection
(a)   Dipyrone
(b)   Hyoscine

One dose of 2.5ml
injected under the skin

(a)    2-3 days
(b)    4-6 days

168 hours
(7 days)
note variation in
excretion rates

It is imperative that this information be read in conjunction with the Notes and Preamble preceding these reports

30

Clenbutarol
(Ventipulmin)

1.5 Gram, 12 Hourly,
for 3 days

48-72 hours

96 hours

31

Coumarin
(Pyrona)

300 mgm, orally
once daily, for 3 days

Nil at 24 hours

48 hours

32

Meloxicam
(Metacam)

1.5 mgm / 7.5 Kg. B. Wt.
in First Dose – Then
1.5 mgm / 15 Kg. B.Wt.,
daily for 4 days.
All doses at 24 hour
intervals.

3 Days in one dog
5 Days in other dog

6 Days
Note variation in excretion times.

33

Robaxin
(Methocarbamol)

1 Tablet (500mgm)
8 Hourly for 5 days

5 Days

6 Days

34

Prednil Tablets
Each containing Prednisolone 5.0 mgm plus Chlorpheniramine Maleate 2.0 mgm

1 Tablet 8 Hourly for 5 days

Prednisolone, 3 daysChlorpheniramine, exceeding 7 days

Not yet defined due to Chlorpheniramine

35

Lignocaine 2% Solution

One dose of 3ml (60 mgm) injected under the skin

24 hours in one dog, but nil at 24 hours in the other

48 hours
Note the variation in excretion rates

36

Prednefrin Forte Eye Drops
Prednisolone Acetate – 1%
Phenylephrine HC1 – 0.12%

One drop applied to each eye, once daily, for 5 days

Prednisolone – Nil at 24 hours
Phenylephrine – Nil at 24 hours

48 hours

37

Rakelin Injection
(Reserpine 0.5 mgm/ml)

0.5 ml (0.25 mgm) into muscle, once daily, for 3 days

72 hours

96 hours

38

Scourban Oral
Anti-Diarrhoeal Suspension

20 ml of Scourban,
(= Hyoscine HBr, 0.8 mgm), orally, 12 hourly, for 3 days

24 hours in one greyhound.
Nil at 24 hours in the other greyhound.

48 hours

The medication Decort 20 (Deoxycortone acetate) is prescribed by veterinarians to combat dehydration in the racing greyhound, when administered in combination with oral electrolytes and water.

39

Decort 20 injection
(20 mgm/ml)

One injection of 1.0ml (20 mgm) into muscle.

Nil at 24 hours

48 hours

The medication Amacin Eye Ointment (Neomycin + Polymixin + Bacitracin + Prednisolone 2.5 mgm/Gm) is prescribed by veterinarians to combat infections &/or inflammation in the eyes of racing greyhounds.

It is imperative that this information be read in conjunction with the Notes and Preamble preceding these reports

40

Amacin Eye Ointment
containing
Prednisolone 2.5mgm
in each Gram

Applying 1.5cm of ointment from the tube, to each eye, twice daily, for 5 days.

Nil at 24 hours

48 hours

The medication Chlorasone Eye Ointment (Chloramphenicol 10 mgm/Gram + Hydrocortisone 5 mgm/Gram) is prescribed by veterinarians to combat infections & / or inflammation in the eye of racing greyhounds.

41

Chlorasone Eye Ointment
Containing
Chloramphenicol 10 mgm/Gm
+ Hydrocortisone 5 mgm/Gm

Applying 1.5 cm of ointment from the tube, to each eye, twice daily for 5 days

Nil at 24 hours for both the Chloramphenicol and Hydrocortisone

48 Hours

The medication EtoGesic (Containing 300 mgm of Etodolac in each Tablet) is prescribed by veterinarians to combat pain and inflammation associated with non-infectious osteoarthritis and post-surgical conditions in greyhounds

42

EtoGesic(Etodolac) Tablets

Administer 1.5 tablets(=450 mgm Etodolac),
once daily, for 5 days

4 Days in one dog,
5 Days in one dog

6 Days
Note variation in excretion rates

It is imperative that this information be read in conjunction with the Notes and Preamble preceding these reports 

 

(Drug Summary/Revised 21.2.2002)

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